The Technology

The ANANAS  are a unique kind  of poly-avidin nanoparticles obtained through a process of natural self-assembly which guarantees high composition and performance reproducibility. The nanoparticles ANANAS can be used alone or in combination with other reactive ANANAS as tools in the diagnostic laboratory and research use. They can be functionalized with multiple biotinylated elements with different properties (antibodies, receptors, fluorophores, drugs, peptides...), that can be placed on their surface at stoichiometrically controlled molar ratios. Depending on the elements inserted, one can obtain nanoparticles with different functional properties. ANANAS nanoparticles are useful in vitro diagnostic such us molecular amplifier of the signal compared to commercially available.


Another application of the same technology currently in advanced study, is the intelligent guidance of drugs and diagnostic elements in the body. The objective is to reduce the toxicity of the treatment by incresing the therapeutic and diagnostic benefits. Through their unique composition and highly controlled size, nanoparticles are able to move freely in the blood stream and can therefore serve as drug carriers and diagnostic benefits. Through their unique composition and highly controlled size, nanoparticles are able to move freely in the blood stream and can therefore serve as drug carriers and diagnostic elements in vivo.

 

 

Related  literature:

[1] Pignatto, M., N. Realdon, et al. (2010). "Optimized avidin nucleic acid nanoassemblies by a tailored PEGylation strategy and their application as molecular amplifiers in detection." Bioconjug Chem 21(7): 1254-1263.

[2] Morpurgo, M., S. Facchin, et al. (2012). "Characterization of multifunctional nanosystems based on the avidin-nucleic acid interaction as signal enhancers in immuno-detection." Anal Chem 84(7): 3433-3439.